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| This issue of the journal coincides with the International Liver Congress 2013 in Amsterdam, the Netherlands. Ira Jacobson, chief of the Division of Gastroenterology and Hepatology and Vincent Astor Distinguished Professor of Medicine at Weill Cornell Medical College, said: The new sofosbuvir therapy offers a much-needed alternative to standard therapy with interferon, which can cause significant side effects for hepatitis C patients. We have dreamed for years of being able to eliminate interferon from our hepatitis C regimens and this study is one of several that are finally bringing us very close to realizing that goal. The patients either had not responded to interferon, were unwilling to use it, or unable to tolerate it, in spite of there being no other treatment options available. Jacobson said This new treatment represents a paradigm shift in the way that hepatitis C is going to be treated.
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We are achieving the same or higher cure rates in many patients with sofosbuvir, compared to interferon, and we are doing it in half the time with a drug that has a remarkable safety profile. The authors estimate that up to 50% of hepatitis C patients are either unable to use interferon or refuse to use it. They see Sofosbuvir as an extremely promising treatment for these patients. They believe that potent antiviral drug combos will eventually replace interferon use for the majority of patients with hepatitis C.
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